Spatial distribution of malignant transformation in patients with low-grade glioma.

作者: Asgeir S Jakola , David Bouget , Ingerid Reinertsen , Anne J Skjulsvik , Lisa Millgård Sagberg

DOI: 10.1007/S11060-020-03391-1

关键词:

摘要: BACKGROUND Malignant transformation represents the natural evolution of diffuse low-grade gliomas (LGG). This is a catastrophic event, causing neurocognitive symptoms, intensified treatment and premature death. However, little known concerning spatial distribution malignant in patients with LGG. MATERIALS AND METHODS Patients histopathological diagnosed LGG subsequent radiological were identified from two different institutions. We evaluated (1) visual inspection (2) segmentations longitudinal tumor volumes. In site   10 ml 93% patients. The site was considered local 91% by clinical assessment. treated radiotherapy prior to had somewhat lower rate transformations (83%). Based upon segmentations, 92%. did not observe any particular pattern examined molecular subgroups. CONCLUSION occurs locally within T2w hyperintensities most Although an infiltrating disease, this data conceptually strengthens role loco-regional treatments

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