The protective effects of intratympanic dexamethasone and vitamin E on cisplatin-induced ototoxicity are demonstrated in rats

摘要: Cisplatin ototoxicity is a major dose-limiting factor in the treatment of several neoplasms. Dexamethasone and vitamin E are two slow-acting free radical cleaners, they have been shown to ameliorate nephrotoxicity endothelial cell damage animals receiving cisplatin. The purpose study was determine effectiveness dexamethasone as an otoprotectant intratympanically. Prospective, randomized controlled trial rat model. Wistar rats were sedated using 50 mg/kg intraperitoneal ketamine 7.5 xylazine. Baseline auditory brainstem response (ABR) testing performed clicks 4.8-, 12-, 16-kHz tone bursts. After thresholds determined, received drug administration according one four groups. groups (group I) % 09 NaCl solution intratympanically (IT), II) cisplatin (20 mg/kg) only intraperitoneally (IP), III) (0.1–0.3 ml) IT IV) followed after 30 min by 20 3-day follow-up, ABR threshold changes recorded. Group II showed marked hearing loss with average shifts 39.7 ± 1.4 dB for clicks, 7.3 2.6 at 4 kHz, 8.4 1.6 8 71.1 4.2 12 kHz 71.9 5.9 16 kHz. No significant observed group III 1.60 1.3 dB, 4.75 2.4 8.7 3.4 4.3 2.1 bursts 4.8, 12, respectively. And similar findings IV 3.3 7.2 10.8 2 13.3 3.1 Significant protection seen compared animals. There no side effect functions them appear easier, safer, usable protective against ototoxicity.