Androgen action and metabolism in prostate cancer
作者： Sean M. Green , Elahe A. Mostaghel , Peter S. Nelson
DOI: 10.1016/J.MCE.2011.09.046
关键词:
摘要: The transcriptional programs regulated through the activity of androgen receptor (AR) modulate normal prostate development and maintenance prostatic functions at maturity. AR signaling also controls key survival growth operative in cancer. Inhibiting program remains target treatment advanced cancer, suppressing holds great potential for preventing or progression early stage In this review, we detail molecular mechanisms activity, cellular components contributing to despite AR–ligand suppression, discuss strategies designed resistance AR-directed therapeutics.
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sci-hub.se 参考文章(131)
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