The lathyrogenic effect of isonicotinic acid hydrazide (INAH) on the chick embryo and its reversal by pyridoxal.

摘要: When applied to the chorio-allantoic membrane of chick embryo, isoniazid was shown produce an increase in fragility embryo and amount collagen which extractable from bones with cold 1 M sodium chloride. The administration pyridoxal reversed these phenomena almost completely. effect differed that β-aminopropionitrile latter greater magnitude, not affected by pyridoxal; whereas caused skeletal deformities, even at 12 times concentration produced no deformities. aldehyde group be necessary for its interaction isoniazid.