Structure of the TPR domain of p67phox in complex with Rac.GTP.
作者： Karine Lapouge , Susan J.M Smith , Philip A Walker , Steven J Gamblin , Stephen J Smerdon
DOI: 10.1016/S1097-2765(05)00091-2
关键词:
摘要: p67 phox is an essential part of the NADPH oxidase, a multiprotein enzyme complex that produces superoxide ions in response to microbial infection. Binding of the small GTPase Rac …
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M de Boer, PM Hilarius-Stokman, JP Hossle, AJ Verhoeven, N Graf, RT Kenney, R Seger, D Roos, Autosomal recessive chronic granulomatous disease with absence of the 67-kD cytosolic NADPH oxidase component: identification of mutation and detection of carriers Blood. ,vol. 83, pp. 531- 536 ,(1994) , 10.1182/BLOOD.V83.2.531.531
C C. P. Ponting, C Phillips, Rapsyn's knobs and holes: eight tetratrico peptide repeats. Biochemical Journal. ,vol. 314, pp. 1053- 1054 ,(1996) , 10.1042/BJ3141053
D. Diekmann, C. D. Nobes, P. D. Burbelo, A. Abo, A. Hall, Rac GTPase interacts with GAPs and target proteins through multiple effector sites. The EMBO Journal. ,vol. 14, pp. 5297- 5305 ,(1995) , 10.1002/J.1460-2075.1995.TB00214.X
Zbyszek Otwinowski, Wladek Minor, Processing of X-ray diffraction data collected in oscillation mode Methods in Enzymology. ,vol. 276, pp. 307- 326 ,(1997) , 10.1016/S0076-6879(97)76066-X
Pablo J. Patiño, Julie Rae, Deborah Noack, Rich Erickson, Jiabing Ding, Diana Garcı́a de Olarte, John T. Curnutte, Molecular characterization of autosomal recessive chronic granulomatous disease caused by a defect of the nicotinamide adenine dinucleotide phosphate (reduced form) oxidase component p67-phox. Blood. ,vol. 94, pp. 2505- 2514 ,(1999) , 10.1182/BLOOD.V94.7.2505.419K10_2505_2514
Ernest D. Laue, Angela Morreale, Meenakshi Venkatesan, Helen R. Mott, Darerca Owen, Daniel Nietlispach, Peter N. Lowe, Structure of Cdc42 bound to the GTPase binding domain of PAK. Nature Structural & Molecular Biology. ,vol. 7, pp. 384- 388 ,(2000) , 10.1038/75158
Jorge Navaza, Pedro Saludjian, [33] AMoRe: An automated molecular replacement program package Methods in Enzymology. ,vol. 276, pp. 581- 594 ,(1997) , 10.1016/S0076-6879(97)76079-8
P G Heyworth, B P Bohl, G M Bokoch, J T Curnutte, Rac translocates independently of the neutrophil NADPH oxidase components p47phox and p67phox. Evidence for its interaction with flavocytochrome b558. Journal of Biological Chemistry. ,vol. 269, pp. 30749- 30752 ,(1994) , 10.1016/S0021-9258(18)47341-3
Bernard M. Babior, NADPH Oxidase: An Update Blood. ,vol. 93, pp. 1464- 1476 ,(1999) , 10.1182/BLOOD.V93.5.1464
G. M. Bokoch, M. A. Schwartz, Xuemin Xu, J. Settleman, D. C. Barry, Differing structural requirements for GTPase-activating protein responsiveness and NADPH oxidase activation by Rac. Journal of Biological Chemistry. ,vol. 269, pp. 23569- 23574 ,(1994) , 10.1016/S0021-9258(17)31553-3