Copper exposure and potential biomarkers of copper metabolism.

摘要: Relevant biological effects associated with mild to moderate copper deficiency and excess are unknown. It is difficult identify markers of these early changes because limits the homeostatic range still undefined may represent adaptive responses that do not imply necessarily risk damage. We report here a series studies carried out shed light on within range, by assessing classic parameters status in humans at different exposure. In adult healthy volunteers had an estimated daily intake 0.9 mg Cu/day (approximately 15 microg/kg/d), exposure additional 50-60 microg copper/kg/day for three months or up 150 microg/kg/d two resulted no significant SOD activity erythrocytes, concentration (in serum, erythrocytes mononuclear cells) serum ceruloplasmin (ANOVA). Neither were found differences gender age. As previous infants, non-ceruloplasmin fraction was positively correlated (r = 0.58). Assessing variations absorption, infants supplemented/not supplemented oral (80 ug/kg/14 days), age 1 3 months, showed absorption close 80% both ages; effect observed supplementation, suggesting either concentrations elicit regulatory mechanisms this down regulation efficient. These indicate homeostasis area tested suitable detect (within range) metabolism.