PILRα Negatively Regulates Mouse Inflammatory Arthritis
作者： Yonglian Sun , Patrick Caplazi , Juan Zhang , Anita Mazloom , Sarah Kummerfeld
关键词:
摘要: Paired Ig-like type 2 receptor (PILR)α inhibitory and its counterpart PILRβ activating are coexpressed on myeloid cells. In this article, we report that PILRα, but not PILRβ, is elevated in human rheumatoid arthritis synovial tissue correlates with inflammatory cell infiltration. Pilrα(-/-) mice produce more pathogenic cytokines during inflammation prone to enhanced autoimmune arthritis. Correspondingly, engaging PILRα anti-PILRα mAb ameliorates mouse models suppresses the production of proinflammatory cytokines. Our studies suggest mediates an important pathway can dampen responses.
jimmunol.org参考文章(44)
Takashi Kagari, Daisuke Tanaka, Hiromi Doi, Takaichi Shimozato, Essential Role of Fcγ Receptors in Anti-Type II Collagen Antibody-Induced Arthritis Journal of Immunology. ,vol. 170, pp. 4318- 4324 ,(2003) , 10.4049/JIMMUNOL.170.8.4318
Ikuo Shiratori, Kouetsu Ogasawara, Takashi Saito, Lewis L. Lanier, Hisashi Arase, Activation of natural killer cells and dendritic cells upon recognition of a novel CD99-like ligand by paired immunoglobulin-like type 2 receptor Journal of Experimental Medicine. ,vol. 199, pp. 525- 533 ,(2004) , 10.1084/JEM.20031885
Robert C Gentleman, Vincent J Carey, Douglas M Bates, Ben Bolstad, Marcel Dettling, Sandrine Dudoit, Byron Ellis, Laurent Gautier, Yongchao Ge, Jeff Gentry, Kurt Hornik, Torsten Hothorn, Wolfgang Huber, Stefano Iacus, Rafael Irizarry, Friedrich Leisch, Cheng Li, Martin Maechler, Anthony J Rossini, Gunther Sawitzki, Colin Smith, Gordon Smyth, Luke Tierney, Jean YH Yang, Jianhua Zhang, None, Bioconductor: open software development for computational biology and bioinformatics Genome Biology. ,vol. 5, pp. 1- 16 ,(2004) , 10.1186/GB-2004-5-10-R80
Takashi Kagari, Hiromi Doi, Takaichi Shimozato, The Importance of IL-1β and TNF-α, and the Noninvolvement of IL-6, in the Development of Monoclonal Antibody-Induced Arthritis Journal of Immunology. ,vol. 169, pp. 1459- 1466 ,(2002) , 10.4049/JIMMUNOL.169.3.1459
Rafael A Irizarry, Bridget Hobbs, Francois Collin, Yasmin D Beazer‐Barclay, Kristen J Antonellis, Uwe Scherf, Terence P Speed, Exploration, normalization, and summaries of high density oligonucleotide array probe level data Biostatistics. ,vol. 4, pp. 249- 264 ,(2003) , 10.1093/BIOSTATISTICS/4.2.249
S P Paul, L S Taylor, D W McVicar, Paired inhibitory and activating receptor signals. Reviews in immunogenetics. ,vol. 2, pp. 204- 219 ,(2000)
R Core Team, R: A language and environment for statistical computing. MSOR connections. ,vol. 1, ,(2014)
Munir Akkaya, A. Neil Barclay, How do pathogens drive the evolution of paired receptors European Journal of Immunology. ,vol. 43, pp. 303- 313 ,(2013) , 10.1002/EJI.201242896
G. K. Smyth, limma: Linear Models for Microarray Data Springer, New York, NY. pp. 397- 420 ,(2005) , 10.1007/0-387-29362-0_23
Brian T. Wipke, Zheng Wang, Wouter Nagengast, David E. Reichert, Paul M. Allen, Staging the Initiation of Autoantibody-Induced Arthritis: A Critical Role for Immune Complexes The Journal of Immunology. ,vol. 172, pp. 7694- 7702 ,(2004) , 10.4049/JIMMUNOL.172.12.7694