Histamine and immune biomarkers in CNS disorders

摘要: Neuroimmune dysregulation is a common phenomenon in different forms of central nervous system (CNS) disorders. Cross-links between and peripheral immune mechanisms appear to be disrupted as reflected by series markers (CD3, CD4, CD7, HLA-DR, CD25, CD28, CD56) which show variability brain disorders such anxiety, depression, psychosis, stroke, Alzheimer’s disease, Parkinson’s attention-deficit hyperactivity disorder, migraine, epilepsy, vascular dementia, mental retardation, cerebrovascular encephalopathy, multiple sclerosis, tumors, cranial nerve neuropathies, posttraumatic injury. Histamine (HA) pleiotropic monoamine involved several neurophysiological functions, neuroimmune regulation, CNS pathogenesis. Changes HA an age- sex-related pattern, alterations levels are present regions patients with disease (AD). Brain neuronal nonneuronal compartments plays dual role (neurotrophic versus neurotoxic) tissue-specific manner. Pathogenic associated AD involve HA, interleukin-1β, TNF-α, whose aberrant expression contributes neuroinflammation aggravating factor for neurodegeneration premature death.