Measurement of unscheduled DNA synthesis on alkylating carcinogens in rat intestinal mucosal cells from different sites.
作者： Hideki MORI , Futoshi OHBAYASHI , Shigeyuki SUGIE , Takuji TANAKA , Masayoshi TAKAHASHI
DOI: 10.2131/JTS.9.23
关键词:
摘要: Unscheduled DNA synthesis (UDS) induced by in vitro exposure to five alkylating carcinogens was measured the mucosal cells from three different sites of rat intestine. The yield UDS N-methyl-N'-nitro-N-nitrosoguanidine or N-ethyl-N'-nitro-N-nitrosoguanidine methylazoxymethanol acetate higher colon & rectum than those jejunum ileum. Conversely, induction N-methyl-N-nitrosourea methyl-methanesulphonate seen at a rather level small intestine compared with rectum.
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