Heat Shock Proteins in Chronic Lymphocytic Leukaemia

摘要: Over the last decade, research has implicated a group of molecular chaperones termed Heat Shock Proteins (HSPs) as major contributors to cancer progression and development chemo-resistance. HSPs were initially discovered proteins that strongly induced in response heat shock other cellular stresses. Under non-stress conditions, they have wide variety roles within many sub-cellular compartments where facilitate protein folding, prevent unfolding assist transport across membranes. Due their maintaining conformation, are vital when start unfold due stress such high temperature, exposure cytotoxic chemicals or oxidative up-regulated rapidly these situations (Ciocca Calderwood, 2005). stressful aggregation, stabilise cell membranes inhibit key steps death pathways (Beere & Green, 2001), thereby enabling survival conditions would otherwise be lethal. Importantly, normal cells, once passed, HSP levels return baseline regular house-keeping duties. However, growing body shows tumour including Chronic Lymphocytic Leukaemia (CLL) remain elevated may contribute prolonged via several mechanisms fully revealed.