What is the best animal model for ACS

作者: A. Schachtrupp , J. Wauters , A. Wilmer

DOI: 10.1179/ACB.2007.62.S1.031

关键词:

摘要: AbstractIntroduction: Current treatment of the abdominal compartment syndrome (ACS) is based on consensus definitions but several questions regarding fluid regime or critical level intra-abdominal hypertension (IAH)) remain unsolved. It questionable whether these issues can be addressed in prospective randomized trials near future. This review aimed to summarize current animal models and outline requirements for best model.Methods: PubMed® data base was searched articles describing ACS.Results: 25 were found. ACS animals has not been defined yet. Investigations varied considerably experimental design. Animals rats, rabbits, dogs pigs with a bodyweight from 200g 70 kg. IAP increase 20 50 mmHg. The time period IAH ranged between 30 min 24h. insult organ dysfunction 15 18h. demonstrated that able induce loss intravascular volume, ...

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