Does motilin regulate canine interdigestive gastric motility?

摘要: Our objective was to determine whether motilin increases the frequency of cyclic interdigestive motor activity in canine proximal stomach. In 4 conscious dogs with autotransplanted gastric pouches and gastrointestinal electrodes, intravenous infusions or (0.6 μg/kg body wt/hr) increased cycles by 30% both pouch main tract. However, 3-min interval between end a cycle duodenum unchanged motilin. control experiments, without infusion, concentration endogenous plasma during intense contractile phase (overall mean, 385 pg/ml) greater each dog (P<0.01) than quiescent 256 pg/ml). The also (mean, 717 587 exogenous two three (P<0.01). We concluded that stomach increase not dependent on intact extrinsic innervation.