The variable region gene assembly mechanism
作者： Ami Okada , Frederick W. Alt
DOI: 10.1016/B978-012053640-5/50013-6
关键词:
摘要: Publisher Summary The mechanism responsible for generating diversity of antigen receptors is the assembly variable (V) region each receptor chain by somatic recombination (V), joining (J), and (D) gene segments. This chapter reviews current understanding V J recombination. or occurs during early stages lymphocyte differentiation, associated with program development. Because V, D, segments that encode can have several members, a significant level be generated from combinatorial these Additional also event. junction assembled V-region encodes third complementarity determining (CDR3) immunoglobulin (Ig) contacts an analogous contact T-cell receptor. Thus, features machinery modify segment ends significantly contribute to increasing repertoires.
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