SCL/Tal-1 transcription factor acts downstream of cloche to specify hematopoietic and vascular progenitors in zebrafish
作者： E. C. Liao , B. H. Paw , A. C. Oates , S. J. Pratt , J. H. Postlethwait
DOI: 10.1101/GAD.12.5.621
关键词:
摘要: SCL/Tal-1 is a transcription factor necessary for hematopoietic stem cell differentiation. Although SCL also expressed in endothelial and neural progenitors, function these cells remains unknown. In the zebrafish mutant cloche (clo), expression nearly abolished vascular tissues. Correspondingly, it was shown previously that clo fails to differentiate blood angioblasts. Genetic analysis demonstrates mutation not linked locus. Forced of embryos rescues defects, suggesting acts downstream specify
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genesdev.org参考文章(38)
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