Mechanisms for dominant follicle selection in monovulatory species: a comparison of morphological, endocrine and intraovarian events in cows, mares and women.

摘要: The selection of a single ovarian follicle for further differentiation and finally ovulation is shared phenomenon in monovulatory species from different phylogenetic classes. commonality dominant (DF) development leads us to hypothesize that mechanisms DF are conserved. This review highlights similarities differences follicular wave growth between cows, mares women, addresses the transient rises FSH concentrations, discusses secretions oestradiol inhibin with their regulatory roles FSH. In all three species, rising concentrations induce emergence cohort attrition occurs during declining culminating selection. Cohort initially responsible FSH, which subsequently suppressed by selected lowering it below threshold requirements other follicles. acquires relative FSH-independence order continue low (cow, mare) or (women), thus may be one lowest requirement due enhanced signalling. transition FSH- LH-dependence postulated as mechanism continued DF. addition, IGF enhance each other's ability stimulate cell function access IGF-I -II type 1 receptor regulated binding proteins turn specific proteases; have been ascribed role development. No fundamental identified studied. Thus functional studies DFs cattle also valuable identifying genes pathways regulating women.