Effect of Acetyl Salicylic Acid and Cetraxate on Human Gastric Mucosal Blood Flow: Clinical Application of Laser Doppler Measurement

作者: Hiroko USUI

DOI: 10.1111/J.1443-1661.1995.TB00393.X

关键词:

摘要: : The effects of acetyl salicylic acid and cetraxate on gastric mucosal blood flow (GMBF) were examined in human subjects. GMBF was determined endoscopically using a laser Doppler flowmeter. normal value 16 adults ranged from 1.7 ± 0.8 volts (mean SD) at the lesser curvature antrum to 3.72 0.79 greater body. In four volunteers, time course measured after oral intake 0.5 g with or without cetraxate. significantly lower 15 min body (3.6 1.0 2.3 0.7, P<0.05) 20 (2.7 0.6 1.4 0.2, P<0.05), as compared values 5 min. This adverse effect inhibited by concomitant administration It concluded that prevented induced decrease GMBF.

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