Gene-gene interaction analysis identifies a new genetic risk factor for colorectal cancer

摘要: Adiponectin levels have been shown to be associated with colorectal cancer (CRC). Furthermore, a newly identified adiponectin receptor, T-cadherin, has plasma levels. Therefore, we investigated the potential for genetic association between T-cadherin and CRC risk. We conducted case–control study using Korean Cancer Prevention study-II cohort, which is composed of 325 patients 977 normal individuals. Study results revealed that rs3865188 in 5’ flanking region gene (CDH13) was significantly (p = 0.0474). The odds ratio (OR) TT genotype as compared TA + AA 1.577 (p = 0.0144). In addition, interaction CDH13 (APN) risk logistic regression analysis. Among six APN single nucleotide polymorphisms (rs182052, rs17366568, rs2241767, rs3821799, rs3774261, rs6773957), an found four (rs2241767, rs6773957). group combined genotypes GG rs377426 displayed highest development those other combinations. OR TT/GG AA/AA 4.108 (p = 0.004). level showed correlation gene-gene interaction, had lowest (median, 4.8 μg/mL vs.7.835 μg/mL genotype, p = 0.0017). present new factor These factors may useful predicting