Effects of genetic variations in the Adiponectin pathway genes on the risk of colorectal cancer in the Chinese population

作者: Bangshun He , Yuqin Pan , Ying Zhang , Qian Bao , Liping Chen

DOI: 10.1186/1471-2350-12-94

关键词: Genetic predispositionOdds ratioColorectal cancerAdiponectinBiologyInternal medicinePolymorphism (computer science)AlleleGenotypeHuman geneticsOncologyEndocrinology

摘要: Background Decreased expression of adiponectin (ADIPOQ) is associated with an increased risk for developing colorectal cancer (CRC) in humans. This study was designed to determine whether polymorphisms present the ADIPOQ and its type 1 receptor (ADIPOR1) could affect CRC.

参考文章(48)
Zhe Dai, Obesity and colorectal cancer risk: A meta-analysis of cohort studies World Journal of Gastroenterology. ,vol. 13, pp. 4199- 4206 ,(2007) , 10.3748/WJG.V13.I31.4199
Laurence N. Kolonel, Lynne R. Wilkens, Jean H. Hankin, Li Ching Lyu, Loïc Le Marchand, Associations of Sedentary Lifestyle, Obesity, Smoking, Alcohol Use, and Diabetes with the Risk of Colorectal Cancer Cancer Research. ,vol. 57, pp. 4787- 4794 ,(1997)
John D. Potter, Martha L. Slattery, Roberd M. Bostick, Susan M. Gapstur, Colon Cancer: A Review of the Epidemiology Epidemiologic Reviews. ,vol. 15, pp. 499- 545 ,(1993) , 10.1093/OXFORDJOURNALS.EPIREV.A036132
Julian Peto, Cancer epidemiology in the last century and the next decade Nature. ,vol. 411, pp. 390- 395 ,(2001) , 10.1038/35077256
Michael J. Thun, Cari J. Connell, Eric J. Jacobs, Eugenia E. Calle, Alpa V. Patel, Marjorie L. McCullough, Vilma E. Cokkinides, Ann Chao, Amount, Type, and Timing of Recreational Physical Activity in Relation to Colon and Rectal Cancer in Older Adults: the Cancer Prevention Study II Nutrition Cohort Cancer Epidemiology, Biomarkers & Prevention. ,vol. 13, pp. 2187- 2195 ,(2004)
N Siitonen, L Pulkkinen, U Mager, Jaana Lindström, JG Eriksson, TT Valle, H Hämäläinen, P Ilanne-Parikka, S Keinänen-Kiukaanniemi, J Tuomilehto, M Laakso, M Uusitupa, Finnish Diabetes Prevention Study Group, None, Association of sequence variations in the gene encoding adiponectin receptor 1 (ADIPOR1) with body size and insulin levels. The Finnish Diabetes Prevention Study Diabetologia. ,vol. 49, pp. 1795- 1805 ,(2006) , 10.1007/S00125-006-0291-7
Eugenia E. Calle, Rudolf Kaaks, Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms Nature Reviews Cancer. ,vol. 4, pp. 579- 591 ,(2004) , 10.1038/NRC1408
Sayaka Otake, Decreased levels of plasma adiponectin associated with increased risk of colorectal cancer World Journal of Gastroenterology. ,vol. 16, pp. 1252- 1257 ,(2010) , 10.3748/WJG.V16.I10.1252
V Cottet, C Bonithon-Kopp, O Kronborg, L Santos, R Andreatta, MC Boutron-Ruault, J Faivre, European Cancer Prevention Organisation Study Group, Dietary patterns and the risk of colorectal adenoma recurrence in a European intervention trial. European Journal of Cancer Prevention. ,vol. 14, pp. 21- 29 ,(2005) , 10.1097/00008469-200502000-00004
Virginia G Kaklamani, Kari B Wisinski, Maureen Sadim, Cassandra Gulden, Albert Do, Kenneth Offit, John A Baron, Habibul Ahsan, Christos Mantzoros, Boris Pasche, Variants of the Adiponectin (ADIPOQ) and Adiponectin Receptor 1 (ADIPOR1) Genes and Colorectal Cancer Risk JAMA. ,vol. 300, pp. 1523- 1531 ,(2008) , 10.1001/JAMA.300.13.1523