The pleiotropic roles of ADAM9 in the biology of solid tumors

摘要: A disintegrin and a metalloprotease (ADAM) 9 is metzincin cell-surface protease involved in several biological processes such as myogenesis, fertilization, cell migration, inflammatory response, proliferation, cell-cell interactions. ADAM9 has been found over-expressed solid tumors entities glioma, melanoma, prostate cancer, pancreatic ductal adenocarcinoma, gastric, breast, lung, liver cancers. Immunohistochemical analyses highlight expression by actual cancer cells associate its abundant presence with clinicopathological features shortened overall survival, poor tumor grade, de-differentiation, therapy resistance, metastasis formation. In each of these tumors, may contribute to biology via proteolytic or non-proteolytic mechanisms. For example, shed MHC class I polypeptide-related sequence A, contributing towards the evasion immunity. also ways probably through interaction different integrins. between β1 integrins facilitates stroma cross talks, which then promotes invasion activation MMP1 MMP2. breast on endothelial facilitate extravasation distant sites. This review summarizes present knowledge cancers, mechanisms it employ drive progression.