The Protective Roles of IL‐6 Trans‐Signaling Regulated by ADAM9 on the Liver in Carbon Tetrachloride‐Induced Liver Injury in Mice
作者： Hua-Jie Lu , San-Qiang Li , Dong-Mei Wang , Sha Zhu , Hong-Ye Meng
DOI: 10.1002/JBT.21714
关键词:
摘要: Our study was undertaken to evaluate the important role that a disintegrin and metalloproteinase 9 (ADAM9) regulates IL-6 trans-signaling in carbon tetrachloride (CCl4)-induced liver injury mice. Mice were divided into four groups. Each group respectively received mineral oil injection, CCl4 anti-ADAM9 monoclonal antibody (mAb) pretreatment mAb recombinant mouse ADAM9 molecules with injection. results showed significantly aggravated injury, inhibited trans-signaling, which led downregulation of proliferating cell nuclear antigen (PCNA), vascular endothelial growth factor (VEGF), upregulation Caspase3, cytochrome P450 2E1 (CYP2E1), hepatocytes apoptosis at 24 h after Recombinant reversed impact In conclusion, our suggested could regulate proliferation, apoptosis, angiogenesis, CYP2E1 expression by activating play protective roles during CCl4-induced
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