Peptide bond formation activated by the interplay of Lewis and Bronsted catalysts

摘要: Abstract The role of Lewis and Bronsted catalysts on the NH3 + HCOOH → NH2CHO + H2O reaction has been studied ab initio using hydrogen fluoride trifluoroaluminum as model systems catalysts, respectively. Both either alone or in combination, have adopted to activate synthesis formamide, simplest a peptide bond containing molecule, by reacting formic acid ammonia. It found that synergy between both dramatically lowers activation barrier for amide formation, fact relevant prebiotic peptides surface oxidic minerals rich Lewis/Bronsted sites.