The Role of Su(Hw) Protein in Transcription Regulation in Drosophila melanogaster
作者： P. V. Elizar’ev , D. A. Chetverina , A. K. Golovnin , P. G. Georgiev , M. M. Erokhin
DOI: 10.1134/S1022795415110058
关键词:
摘要: Insulators are regulatory DNA elements that modulate the effect of enhancers and silencers on gene transcription. However, role insulator complex proteins in expression specific genes remains scarcely studied. In present study, we examined Su(Hw)-dependent transcription rap, CG32810, RpS15Aa genes. It was demonstrated interaction Su(Hw) Mod(mdg4)-67.2 with terminator regions selected dependent factor. At same time, CP190 protein also interacts promoter absence Su(Hw). addition, does not affect level silencing efficiency models. A possible explanation for these results is existence another factor, a able to recruit functionally compensate lack protein.
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