Differential Distribution of CD4+CD25bright and CD8+CD28− T-cells in Decidua and Maternal Blood During Human Pregnancy
作者： T TILBURGS , D ROELEN , B VANDERMAST , J VANSCHIP , C KLEIJBURG
DOI: 10.1016/J.PLACENTA.2005.11.008
关键词:
摘要: During pregnancy several maternal and fetal mechanisms are established to prevent a destructive immune response against the allogeneic fetus. Despite these mechanisms, fetus specific T-cells persist throughout gestation but little is known about regulation of T-cells. Recently, CD4 + CD25 regulatory have been identified in human decidua. Human decidua forms part fetal–maternal interface subdivided two distinct regions: (d.) basalis parietalis. The aim this study was determine distribution T-cell subsets d. parietalis early term pregnancy, with special emphasis on presence bright (regulatory) CD8 CD28 − (suppressor) In addition, we compared phenotypic characteristics derived peripheral blood (mPBL) from non-pregnant controls. We significantly higher percentages suggesting an important role for locally at interface. major differences subset additional between basalis, mPBL may reflect immunomodulatory functions different sites during pregnancy.
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