Analysis of peripheral immune activation in schizophrenia using quantitative reverse-transcription polymerase chain reaction (RT-PCR)
作者： Oliver Freudenreich , Mark A. Brockman , David C. Henderson , A. Eden Evins , Xiaoduo Fan
DOI: 10.1016/J.PSYCHRES.2008.11.007
关键词:
摘要: Immune system abnormalities in schizophrenia include a shift from Type 1 (cellular) to 2 (humoral) immune response. To characterize the activation status of schizophrenia, we examined pattern gene expression peripheral blood cells for three Th1 cytokines (interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha), interleukin-2 (IL-2)), and one Th2 cytokine (interleukin-10 (IL-10)). In cross-sectional study, used quantitative reverse-transcription polymerase chain reaction (RT-PCR) compare mRNA levels IFN-gamma, TNF-alpha, IL-2, IL-10 mononuclear (PBMCs) between 15 patients matched healthy controls. Expression IFN-gamma TNF-alpha was significantly reduced with compared normal No differences IL-2 were observed. These results are consistent impaired cellular immunity schizophrenia. While data illustrate potential utility mRNA-based approaches identification analysis biomarkers neuropsychiatric disorders, correlation direct measures concentrations is required.
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