Methimazole‐induced agranulocytosis: Growth inhibition of myeloid progenitor cells by the patient's serum
作者： Dan Douer , Zemach Eisenstein
DOI: 10.1111/J.1600-0609.1988.TB00803.X
关键词:
摘要: Abstract The mechanism for agranulocytosis induced by antithyroid drugs is not established. few available studies have proposed an immune-mediated process against mature granulocytes. We investigated the effect of methimazole and propylthiouracil serum from a patient with methimazole-induced on marrow myeloid colony growth. In presence normal or patient's recovery serum, had no growth CFU-GM colonies marrow. However, obtained during inhibited in vitro both autologous allogeneic bone These results are compatible rather than direct toxic drug abnormally sensitive cells.
sci-hub.se 参考文章(12)
R Taetle, TA Lane, J Mendelsohn, Drug-induced agranulocytosis: in vitro evidence for immune suppression of granulopoiesis and a cross-reacting lymphocyte antibody. Blood. ,vol. 54, pp. 501- 512 ,(1979) , 10.1182/BLOOD.V54.2.501.501
M. M. Guffy, Granulocytotoxic antibodies in a patient with propylthiouracil-induced agranulocytosis Archives of Internal Medicine. ,vol. 144, pp. 1687- 1688 ,(1984) , 10.1001/ARCHINTE.144.8.1687
DAVID S. COOPER, Agranulocytosis Associated with Antithyroid Drugs Annals of Internal Medicine. ,vol. 98, pp. 26- 29 ,(1983) , 10.7326/0003-4819-98-1-26
A J Barrett, E Weller, N Rozengurt, P Longhurst, J G Humble, Amidopyrine agranulocytosis:drug inhibition of granulocyte colonies in the presence of patient's serum. BMJ. ,vol. 2, pp. 850- 851 ,(1976) , 10.1136/BMJ.2.6040.850-A
Dan Douer, H Phillip Koeffler, Retinoic acid enhances colony-stimulating factor-induced clonal growth of normal human myeloid progenitor cells in vitro☆ Experimental Cell Research. ,vol. 138, pp. 193- 198 ,(1982) , 10.1016/0014-4827(82)90105-7
J. R. WALL, S. L. FANG, T. KUROKI, S. H. INGABAR, L. E. BRAVERMAN, In vitro immunoreactivity to propylthiouracil, methimazole, and carbimazole in patients with Graves' disease: a possible cause of antithyroid drug-induced agranulocytosis. The Journal of Clinical Endocrinology and Metabolism. ,vol. 58, pp. 868- 872 ,(1984) , 10.1210/JCEM-58-5-868
SigmundA. Weitzman, ThomasP. Stossel, Drug-induced immunological neutropenia. The Lancet. ,vol. 311, pp. 1068- 1072 ,(1978) , 10.1016/S0140-6736(78)90915-7
J. A. PITTMAN, R. J. BESCHI, T. C. SMITHERMAN, Methimazole: its absorption and excretion in man and tissue distribution in rats. The Journal of Clinical Endocrinology and Metabolism. ,vol. 33, pp. 182- 185 ,(1971) , 10.1210/JCEM-33-2-182
John G. Kelton, Andrew T. Huang, Nelda Mold, Gerald Logue, Wendell F. Rosse, The Use of in Vitro Technics to Study Drug-Induced Pancytopenia New England Journal of Medicine. ,vol. 301, pp. 621- 624 ,(1979) , 10.1056/NEJM197909203011201
JAMES F. MCMURRY, PAUL F. GILLILAND, CHARLES R. RATLIFF, PHILIP D. BOURLAND, Pharmacodynamics of Propylthiouracil in Normal and Hyperthyroid Subjects After a Single Oral Dose The Journal of Clinical Endocrinology and Metabolism. ,vol. 41, pp. 362- 364 ,(1975) , 10.1210/JCEM-41-2-362