Interactions of Drugs with Liver Microsomes
作者： Ingeborg Schuster
DOI: 10.1007/978-3-642-66626-1_2
关键词:
摘要: The history of microsomes dates back to 1938 when CLAUDE first detected a new cell fraction in mammalian cells. For these particles, which could be isolated by differential centrifugation and afterward observed dark field microscope “as fine granules,” he proposed the term (CLAUDE, 1943). With newly evolving technique electron microscopy it was then proved that resembled form endoplasmic reticulum (CLAUDE et al., 1947; PALADE SIEKEVITZ, 1956).
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