Genetic moderation of CO2-induced fear by 5-HTTLPR genotype
作者： Koen Schruers , Gabriel Esquivel , Marlies van Duinen , Marieke Wichers , Gunter Kenis
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摘要: Inhalation of an increased concentration carbon dioxide (CO2) has been shown to induce a state negative affect in healthy subjects that is closely related the clinical phenomenon panic. It suggested vulnerability CO2 moderated by differences serotonin (5-HT) activity, caused functional polymorphism promoter region 5-HT transporter (5-HTTLPR) gene. Our aim was examine relationship between bi- and tri-allelic 5-HTTLPR genotype affective response different dosages inhaled volunteers. Ninety-six performed double inhalation four mixtures containing, respectively, 0%, 9%, 17.5% 35% CO2, following double-blind, cross-over, randomized design. Affective responses were measured with visual analogue scale for fear Panic Symptom List. expressed as LL, SL SS. Subjects SS reported less than LL subjects. A significant interaction effect fo...
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