Panic disorder is associated with the serotonin transporter gene ( SLC6A4 ) but not the promoter region (5-HTTLPR)

摘要: Panic disorder (PD) and social anxiety (SAD) are moderately heritable disorders. We analyzed five genes, derived from pharmacological or translational mouse models, in a new case-control study of PD SAD European Americans: (1) the serotonin transporter (SLC6A4), (2) receptor 1A, (3) catechol-O-methyltransferase, (4) regulator g-protein signaling (5) gastrin-releasing peptide receptor. Cases were interviewed using schedule for affective disorders schizophrenia required to have probable definite lifetime diagnosis (N=179), (161) both (140), with first onset by age 31 family history anxiety. Final diagnoses determined best estimate procedure, blind genotyping data. Controls obtained National Institute Mental Health Human Genetics Initiative; only subjects above 25 years who screened negative all psychiatric symptoms included (N=470). A total 45 single nucleotide polymorphisms successfully genotyped over selected genes Applied Biosystems SNPlex protocol. SLC6A4 provided strong consistent evidence association PD+SAD groups, most significant groups being at rs140701 (chi(2)=10.72, P=0.001 chi(2)=8.59, P=0.003 group). This remained after multiple test correction. Those carrying least one copy haplotype A-A-G constructed rs3794808, rs4583306 1.7 times odds than those without (95% confidence interval: 1.2-2.3). The group did not provide association, suggesting PD-driven association. findings adjustment sex, there was no that due population stratification. promoter region gene, 5-HTTLPR, any regardless whether as triallelic biallelic locus, nor other four candidate tested. Our suggest gene may play role PD; however, require replication. Future studies should attend entire genetic rather promoter.