The extrathyroidal effect of D,L-propranolol on 3,3',5'-triiodothyronine, 3',5'-diiodothyronine, 3,3'-diiodothyronine, and 3'-monoiodothyronine kinetics.
作者： I. B. LUMHOLTZ , J. FABER , C. KIRKEGAARD , K. SIERSBÆK-NIELSEN , T. FRIIS
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摘要: The effect of D,L-propranolol (80 mg daily) on the peripheral monodeiodination rT3, 3',5'-diiodothyronine (3',5'-T2), 3,3'-diiodothyronine (3,3'-T2), and 3'-monoiodothyronine (3'-T1) was studied in seven out-patients with severe pretreatment hypothyroidism. patients were maintained euthyroid a constant L-T4 replacement therapy. A bolus injection technique used; MCR, production rate (PR), conversion determined using noncompartmental kinetic model. During D,L-propranolol, serum rT3 3',5'-T2 increased (P less than 0.02), 3,3'-T2 seemed to decrease. MCRs 3',5'-T2, 0.02) decreased during drug treatment. MCR PR 3'-T1 reduced, albeit not significantly 0.10). reduced whereas PRs unaltered. No changes seen apparent distribution volumes iodothyronines studied. results are compatible assumption that or metabolite thereof, inhibits 5'-deiodination all iodothyronines.
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sci-hub.se 参考文章(36)
J. SAUNDERS, SUSAN E. H. HALL, A. CROWTHER, P. H. SÖNKSEN, THE EFFECT OF PROPRANOLOL ON THYROID HORMONES AND OXYGEN CONSUMPTION IN THYROTOXICOSIS Clinical Endocrinology. ,vol. 9, pp. 67- 72 ,(1978) , 10.1111/J.1365-2265.1978.TB03573.X
R.P. Verhoeven, T.J. Visser, R. Docter, G. Hennemann, M.A.D.H. Schalekamp, PLASMA THYROXINE, 3,3′,5-TRIIODOTHYRONINE AND 3,3′,5′-TRIIODOTHYRONINE DURING 3-ADRENERGIC BLOCKADE IN. HYPERTHYROIDISM The Journal of Clinical Endocrinology and Metabolism. ,vol. 44, pp. 1002- 1005 ,(1977) , 10.1210/JCEM-44-5-1002
W. M. WIERSINGA, J. L. TOUBER, The Influence of β-Adrenoceptor Blocking Agents on Plasma Thyroxine and Triiodothyronine The Journal of Clinical Endocrinology and Metabolism. ,vol. 45, pp. 293- 298 ,(1977) , 10.1210/JCEM-45-2-293
P. Theilade, J.M. Hansen, L. Skovsted, J. Faber, C. Kirkegård, T. Friis, K. Siersbaek-Nielsen, PROPRANOLOL INFLUENCES SERUM T3 AND REVERSE T3 IN HYPERTHYROIDISM The Lancet. ,vol. 310, pp. 363- ,(1977) , 10.1016/S0140-6736(77)91532-X
Ove R. Nilsson, Bengt E. Karlberg, Bertil Kågedal, Lennart Tegler, Sven Almqvist, Non-Selective and Selective β-1-Adrenoceptor Blocking Agents in the Treatment of Hyperthyroidism Acta Medica Scandinavica. ,vol. 206, pp. 21- 25 ,(2009) , 10.1111/J.0954-6820.1979.TB13463.X
INDER J. CHOPRA, Characteristics of outer ring (5'- or 3'-) monodeiodination of 3',5'- and 3,3'-diiodothyronine: evidence suggesting one outer ring monodeiodinase for various iodothyronines. Endocrinology. ,vol. 108, pp. 464- 471 ,(1981) , 10.1210/ENDO-108-2-464
O. R. Nilsson, A. Melander, L. Tegler, Effects and plasma levels of propranolol and metoprolol in hyperthyroid patients. European Journal of Clinical Pharmacology. ,vol. 18, pp. 315- 320 ,(1980) , 10.1007/BF00561388
P Heyma, R G Larkins, L Higginbotham, K W Ng, D-propranolol and DL-propranolol both decrease conversion of L-thyroxine to L-triiodothyronine. BMJ. ,vol. 281, pp. 24- 25 ,(1980) , 10.1136/BMJ.281.6232.24
L. Wong, RL Nation, WL Chiou, PK Mehta, Plasma concentrations of propranolol and 4‐hydroxypropranolol during chronic oral propranolol therapy. British Journal of Clinical Pharmacology. ,vol. 8, pp. 163- 167 ,(1979) , 10.1111/J.1365-2125.1979.TB05815.X
KENNETH D. BURMAN, FRANCES D. WRIGHT, ROBERT C. SMALLRIDGE, BILL J. GREEN, LEON P. GEORGES, LEONARD WARTOFSKY, A radioimmunoassay for 3',5'-diiodothyronine. The Journal of Clinical Endocrinology and Metabolism. ,vol. 47, pp. 1059- 1064 ,(1978) , 10.1210/JCEM-47-5-1059