Specific transforming potential of oncogenes encoding protein-tyrosine kinases.

摘要: Several chimeric murine retroviruses were constructed to test whether the gag sequence of Abelson leukemia virus (A-MuLV) could influence in vitro specificity two sarcoma-inducing oncogenes: src Rous sarcoma and fps Fujinami virus. Although src- or fps- containing chimerae transform fibroblasts, they unable mimic action A-MuLV causing lymphoid transformation vitro. A-MuLV-derived sequences could, however, functionally replace 5' end restore potential a 5'-truncated gene. To investigate this functional similarity, we replaced an with src. This recombinant behaved like from which it was derived: transformed both fibroblasts cells Taken together, these results suggest that is specific property abl not fps. Furthermore, shows homology exists between