Potential significance of genomic imprinting defects for reproduction and assisted reproductive technology

摘要: Recent studies suggest a possible link between human assisted reproductive technology and genomic imprinting disorders. Assisted includes the isolation, handling culture of gametes early embryos at times when imprinted genes are likely to be particularly vulnerable external influences. Evidence sex-specific differences in imprint acquisition suggests that male female germ cells may susceptible perturbations specific prenatal postnatal stages. Imprints acquired first during gametogenesis must maintained preimplantation development reprogramming overall genome occurs. In this review, we will discuss both new developments our understanding including mechanisms timing erasure, maintenance cell embryogenesis as well implications research for future epigenetic reproduction technology.