Effect of subzero-balanced ultrafiltration on postoperative outcome of patients after cardiopulmonary bypass.

作者: Tao Zhang , Chang-qing Gao , Jia-chun Li , Jia-li Wang , Li-bing Li

DOI: 10.1177/0267659109357977

关键词:

摘要: Objective To evaluate the effect of a new ultrafiltration technique - subzero-balanced on early postoperative outcomes adult patients undergoing cardiac operations with cardiopulmonary bypass. Methods A total 120 who required bypass for surgery were randomized into two groups, 60 in each group. Patients treatment group received during bypass, while control routine Postoperative outcomes, including hospital mortality and morbidity analyzed. Results Hospital was 0% (0 60) versus 1.8% (1 (P=1.000). Total complications lower treated (11 [18.3%] 22 [36.7%], P=0.025). Duration intubation time shorter transfusion volume within 24 hours postoperatively less having (14.35 + or 1.66 18.64 1.57 h, P=0.036 1.54 1.56 3.64 2.67 U/patient, P=0.032). Length stay intensive care unit, duration stay, need infusion inotropic agent drainage volumes h between groups comparable. Conclusions Subzero-balanced can effectively decrease patients' blood transfusion: it also may promote recovery patients. Routine application should not be necessary, but compared to other techniques, e.g. MUF, further studies.

参考文章(25)
Laurence A. Harker, Thomas W. Malpass, Sherrill J. Slichter, Herman E. Branson, Eugene A. Hessel, Mechanism of abnormal bleeding in patients undergoing cardiopulmonary bypass: acquired transient platelet dysfunction associated with selective alpha-granule release. Blood. ,vol. 56, pp. 824- 834 ,(1980) , 10.1182/BLOOD.V56.5.824.824
David W Holt, Lee Stichka, Scott Turner, Rick A Kuntz, Bryan Thacker, Effects of conventional ultrafiltration on renal performance during adult cardiopulmonary bypass procedures. The journal of extra-corporeal technology. ,vol. 38, pp. 144- 153 ,(2006)
Alaa-Basiouni S. Mahmoud, Mohamed S. Burhani, Ali A. Hannef, Ahmad A. Jamjoom, Iskander S. Al-Githmi, Ghassan M. Baslaim, Effect of Modified Ultrafiltration on Pulmonary Function After Cardiopulmonary Bypass Chest. ,vol. 128, pp. 3447- 3453 ,(2005) , 10.1016/S0012-3692(15)52915-2
Ko Bando, Mark W Turrentine, Palaniswamy Vijay, Thomas G Sharp, Yasuo Sekine, Brian J Lalone, Laszlo Szekely, John W Brown, Effect of modified ultrafiltration in high-risk patients undergoing operations for congenital heart disease. The Annals of Thoracic Surgery. ,vol. 66, pp. 821- 827 ,(1998) , 10.1016/S0003-4975(98)00606-7
Christopher F Mojcik, Jerrold H Levy, Aprotinin and the systemic inflammatory response after cardiopulmonary bypass. The Annals of Thoracic Surgery. ,vol. 71, pp. 745- 754 ,(2001) , 10.1016/S0003-4975(00)02218-9
Huimin Huang, Tingjun Yao, Wei Wang, Deming Zhu, Wei Zhang, Hong Chen, Weiding Fu, Continuous ultrafiltration attenuates the pulmonary injury that follows open heart surgery with cardiopulmonary bypass The Annals of Thoracic Surgery. ,vol. 76, pp. 136- 140 ,(2003) , 10.1016/S0003-4975(03)00264-9
J. H. Holmes IV, N. C. Connolly, D. L. Paull, M. E. Hill, S. W. Guyton, S. F. Ziegler, R. A. Hall, Magnitude of the inflammatory response to cardiopulmonary bypass and its relation to adverse clinical outcomes. Inflammation Research. ,vol. 51, pp. 579- 586 ,(2002) , 10.1007/PL00012432
Bruce E. Miller, Jerrold H. Levy, The inflammatory response to cardiopulmonary bypass Journal of Cardiothoracic and Vascular Anesthesia. ,vol. 11, pp. 355- 366 ,(1997) , 10.1016/S1053-0770(97)90106-3
Song Wan, Jean-Louis LeClerc, Jean-Louis Vincent, Inflammatory Response to Cardiopulmonary Bypass: Mechanisms Involved and Possible Therapeutic Strategies Chest. ,vol. 112, pp. 676- 692 ,(1997) , 10.1378/CHEST.112.3.676