Detection of the Epstein-Barr virus in primary adenocarcinoma of the lung with Signet-ring cells.

摘要: The Epstein-Barr virus (EBV) is directly implicated in the pathogenesis of a variety undifferentiated carcinomas and has also been identified conventional adenocarcinomas stomach. To date, association EBV with non-small cell lung carcinoma restricted to Asian patients. evaluate presence cancers from Europeans, we investigated primary similar morphological tumour pattern those stomach, specifically rare tumours components signet-ring cells. Three type were examined by means polymerase chain reaction (PCR). localise neoplastic cells, situ hybridisation (ISH) was performed using an antisense encoded RNA probe. Immunohistochemistry expression latent membrane protein-1 (LMP-1) nuclear antigen 2 (EBNA-2). PCR investigation confirmed one case. Positive signals confined cells present on ISH. None showed LMP-1 EBNA-2. our knowledge, this first report adenocarcinoma Caucasian patient. study indicates that may infect some specific pattern.