act up controls actin polymerization to alter cell shape and restrict Hedgehog signaling in the Drosophila eye disc.

摘要: Abstract Cells in the morphogenetic furrow of Drosophila eye disc undergo a striking shape change immediately prior to their neuronal differentiation. We have isolated mutations novel gene act up (acu ), that is required for this change. acu encodes homolog yeast cyclase-associated protein, which sequesters monomeric actin; we show prevent actin filament polymerization disc. In contrast, profilin promotes polymerization, acting epistatically . However, both and are premature Hedgehog-induced photoreceptor differentiation ahead furrow. These findings suggest dynamic changes filaments alter cell control movement signals coordinate wave