Genetic mapping with SNP markers in Drosophila.
作者： Jürg Berger , Takashi Suzuki , Kirsten-André Senti , Janine Stubbs , Gotthold Schaffner
DOI: 10.1038/NG773
关键词:
摘要: Map-based positional cloning of Drosophila melanogaster genes is hampered by both the time-consuming, error-prone nature traditional methods for genetic mapping and difficulties in aligning cytological maps with genome sequence. The identification sequence polymorphisms will make it possible to map mutations directly high accuracy resolution. Here we report 7,223 single-nucleotide (SNPs) 1,392 insertions/deletions (InDels) common laboratory strains Drosophila. These define a 787 autosomal marker loci resolution 114 kb. We have established PCR product-length polymorphism (PLP) or restriction fragment-length (RFLP) assays 215 these markers. demonstrate use this delimiting two intervals 169 kb 307 kb, respectively. Using local high-density SNP map, also mapped third mutation approximately 2 sufficient localize within single gene. should accelerate rate
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