Efficacy of omega-3 in treatment of recurrent aphthous stomatitis and improvement of quality of life: a randomized, double-blind, placebo-controlled study
作者： Amr M. El khouli , Enas Ahmed El-Gendy
DOI: 10.1016/J.OOOO.2013.09.003
关键词:
摘要: Objective This study assessed the effects of systemic omega-3 on treatment recurrent aphthous stomatitis and improvement quality life. Study Design Fifty participants were randomly assigned to receive either (1 g, 3 times daily) or placebo for 6 months. Assessment outcome measures including monthly number new ulcers, average duration ulcer episodes, pain level ulcers was carried out at baseline Analysis potential impact life using Oral Health Impact Profile 14 Results Daily achieved a significant reduction in by months that persisted Mean score also significantly improved Conclusions A daily regimen shows promise as therapy management patients with stomatitis.
elsevier.com
sci-hub.se 参考文章(30)
Locker D, Measuring oral health: a conceptual framework. Community Dental Health. ,vol. 5, pp. 3- 18 ,(1988)
Philip M. Preshaw, Paula Grainger, Mark H. Bradshaw, Abdel R. Mohammad, Chris V. Powala, Anita Nolan, Subantimicrobial dose doxycycline in the treatment of recurrent oral aphthous ulceration: a pilot study. Journal of Oral Pathology & Medicine. ,vol. 36, pp. 236- 240 ,(2007) , 10.1111/J.1600-0714.2007.00507.X
A. M. Elkhouli, The efficacy of host response modulation therapy (omega-3 plus low-dose aspirin) as an adjunctive treatment of chronic periodontitis (clinical and biochemical study). Journal of Periodontal Research. ,vol. 46, pp. 261- 268 ,(2011) , 10.1111/J.1600-0765.2010.01336.X
S. Q. Alam, B. M. Bergens, B. S. Alam, Arachidonic acid, prostaglandin E2 and leukotriene C4 levels in gingiva and submandibular salivary glands of rats fed diets containing n-3 fatty acids. Lipids. ,vol. 26, pp. 895- 900 ,(1991) , 10.1007/BF02535974
Jaya T. Venkatraman, Bysani Chandrasekar, Jong Dai Kim, Gabriel Fernandes, Effects of n−3 and n−6 fatty acids on the activities and expression of hepatic antioxidant enzymes in autoimmune‐prone NZB×NZW F1 mice Lipids. ,vol. 29, pp. 561- 568 ,(1994) , 10.1007/BF02536628
Nachum Samet, Caroline Laurent, Srinivas M Susarla, Naama Samet-Rubinsteen, None, The effect of bee propolis on recurrent aphthous stomatitis: a pilot study Clinical Oral Investigations. ,vol. 11, pp. 143- 147 ,(2007) , 10.1007/S00784-006-0090-Z
B. Murray, P. A. Biagioni, P.-J. Lamey, The efficacy of amelxanox OraDiscTM on the prevention of recurrent minor aphthous ulceration Journal of Oral Pathology & Medicine. ,vol. 35, pp. 117- 122 ,(2006) , 10.1111/J.1600-0714.2006.00379.X
Li-Jun Liu, Wen Xiao, Qing-Bo He, Wei-Wen Jiang, Generic and oral quality of life is affected by oral mucosal diseases BMC Oral Health. ,vol. 12, pp. 2- 2 ,(2012) , 10.1186/1472-6831-12-2
Andy Sun, Jeng-Tzung Wang, Jean-San Chia, Chun-Pin Chiang, Levamisole can modulate the serum tumor necrosis factor-alpha level in patients with recurrent aphthous ulcerations. Journal of Oral Pathology & Medicine. ,vol. 35, pp. 111- 116 ,(2006) , 10.1111/J.1600-0714.2006.00383.X
Dale A. Miles, Steven L. Bricker, Thomas F. Razmus, Rosario H. Potter, Triamcinolone acetonide versus chlorhexidine for treatment of recurrent stomatitis. Oral Surgery, Oral Medicine, Oral Pathology. ,vol. 75, pp. 397- 402 ,(1993) , 10.1016/0030-4220(93)90158-Z