Subantimicrobial dose doxycycline in the treatment of recurrent oral aphthous ulceration: a pilot study.
作者： Philip M. Preshaw , Paula Grainger , Mark H. Bradshaw , Abdel R. Mohammad , Chris V. Powala
DOI: 10.1111/J.1600-0714.2007.00507.X
关键词:
摘要: Background: Recurrent oral aphthous ulceration (ROAU) is a common problem that can result in considerable pain and distress for patients. The aim of this pilot study was to evaluate the role subantimicrobial dose doxycycline (SDD – 20 mg twice daily) management patients with ROAU. Methods: 50 ROAU were randomly allocated treatment SDD or placebo 90 days. Daily ulcer diaries completed by participants record number new ulcers associated ulcers. Results: There significantly more days no group (80.4 ± 5.9) than (69.8 ± 18.7; P = 0.04). Strong trends observed towards fewer per day, over 90-day period, compared (P = 0.06–0.08). Conclusion: shows promise as potential therapy ROAU, though needs be confirmed further studies.
sci-hub.se 参考文章(31)
A.C. Thompson, A. Nolan, P.-J. Lamey, Minor aphthous oral ulceration: a double-blind cross-over study of beclomethasone dipropionate aerosol spray. Scottish Medical Journal. ,vol. 34, pp. 531- 532 ,(1989) , 10.1177/003693308903400509
Robert W. Barrons, Treatment strategies for recurrent oral aphthous ulcers. American Journal of Health-system Pharmacy. ,vol. 58, pp. 41- 50 ,(2001) , 10.1093/AJHP/58.1.41
S. Silverman, F. Lozada-Nur, C. Migliorati, Clinical efficacy of prednisone in the treatment of patients with oral inflammatory ulcerative diseases: a study of fifty-five patients. Oral Surgery, Oral Medicine, Oral Pathology. ,vol. 59, pp. 360- 363 ,(1985) , 10.1016/0030-4220(85)90060-X
Naotomo Kanbe, Akane Tanaka, Michiyo Kanbe, Atsuko Itakura, Motohiro Kurosawa, Hiroshi Matsuda, Human mast cells produce matrix metalloproteinase 9. European Journal of Immunology. ,vol. 29, pp. 2645- 2649 ,(1999) , 10.1002/(SICI)1521-4141(199908)29:08<2645::AID-IMMU2645>3.0.CO;2-1
M Addy, L Tapper-Jones, M Seal, Trial of astringent and antibacterial mouthwashes in the management of recurrent aphthous ulceration. British Dental Journal. ,vol. 136, pp. 452- 455 ,(1974) , 10.1038/SJ.BDJ.4803212
C. Sandler, E. Ekokoski, K. A. Lindstedt, P. J. Vainio, M. Finel, T. Sorsa, P. T. Kovanen, L. M. Golub, K. K. Eklund, Chemically modified tetracycline (CMT)-3 inhibits histamine release and cytokine production in mast cells: possible involvement of protein kinase C. Inflammation Research. ,vol. 54, pp. 304- 312 ,(2005) , 10.1007/S00011-005-1358-5
Robert Skidmore, Rodney Kovach, Clay Walker, John Thomas, Mark Bradshaw, James Leyden, Christopher Powala, Robert Ashley, Effects of subantimicrobial-dose doxycycline in the treatment of moderate acne. Archives of Dermatology. ,vol. 139, pp. 459- 464 ,(2003) , 10.1001/ARCHDERM.139.4.459
L. M. Golub, H. M. Lee, R. A. Greenwald, M. E. Ryan, T. Sorsa, T. Salo, W. V. Giannobile, A matrix metalloproteinase inhibitor reduces bone-type collagen degradation fragments and specific collagenases in gingival crevicular fluid during adult periodontitis Inflammation Research. ,vol. 46, pp. 310- 319 ,(1997) , 10.1007/S000110050193
David E. Frost, Wayne W. Barkmeier, Herbert Abrams, Aphthous ulcer — A treatment complication Oral Surgery, Oral Medicine, Oral Pathology. ,vol. 45, pp. 863- 869 ,(1978) , 10.1016/S0030-4220(78)80007-3
Ritva Hayrinen-Immonen, Timo Sorsa, Juha Pettila, Yrjo T. Konttinen, Olli Teronen, Maria Malmstrom, Effect of tetracyclines on collagenase activity in patients with recurrent aphthous ulcers Journal of Oral Pathology & Medicine. ,vol. 23, pp. 269- 272 ,(1994) , 10.1111/J.1600-0714.1994.TB00057.X