microRNA-802 inhibits cell proliferation and induces apoptosis in human cervical cancer by targeting serine/arginine-rich splicing factor 9.
作者： Qianwen Zhang , Rui Lv , Wenjia Guo , Xiaoning Li
DOI: 10.1002/JCB.28321
关键词:
摘要: microRNAs (miRNAs) play crucial roles in cancer development and progression by targeting mRNAs for degradation and/or translational repression. microRNA-802 (miR-802) has been reported as a tumor suppressor its deregulation is observed various human cancers. However, the prognostic value of miR-802 underlying mechanisms involved cervical are poorly investigated. The purposes this study were to explore role clarify regulation serine/arginine-rich splicing factor 9 (SRSF9) miR-802. Here, we found that was downregulated both tissues cell lines. Transfection mimic into cells inhibited their proliferation colony formation, promoted cycle arrest at G0/G1 phase apoptosis. In addition, could directly target 3'-untranslated region SRSF9 suppress expression. Rescue experiments revealed overexpression partially reversed inhibition effect cells. Overall, these findings demonstrate functions SRSF9, suggesting might serve potential therapeutic cancer.
sci-hub.se 参考文章(24)
Peter Gocze, Katalin Gocze, Istvan Kiss, Katalin Gombos, Krisztina Juhasz, Krisztina Kovacs, MicroRNA expressions in HPV-induced cervical dysplasia and cancer. Anticancer Research. ,vol. 35, pp. 523- 530 ,(2015)
Shweta Sharma, Showket Hussain, Kartik Soni, Pallavi Singhal, Richa Tripathi, VG Ramachandran, Sonal Sharma, Shukla Das, Beena Pillai, Mausumi Bharadwaj, None, Novel MicroRNA signatures in HPV-mediated cervical carcinogenesis in Indian women Tumor Biology. ,vol. 37, pp. 4585- 4595 ,(2016) , 10.1007/S13277-015-4248-7
Yu Fu, Binlu Huang, Zhen Shi, Jiayu Han, Ying Wang, Jieqiong Huangfu, Wei Wu, SRSF1 and SRSF9 RNA binding proteins promote Wnt signalling-mediated tumorigenesis by enhancing β-catenin biosynthesis. Embo Molecular Medicine. ,vol. 5, pp. 737- 750 ,(2013) , 10.1002/EMMM.201202218
Martin D. Jansson, Anders H. Lund, MicroRNA and cancer Molecular Oncology. ,vol. 6, pp. 590- 610 ,(2012) , 10.1016/J.MOLONC.2012.09.006
Gustavo Bressan, Eduardo Moraes, Adriana Manfiolli, Tais Kuniyoshi, Dario Passos, Marcelo Gomes, Jörg Kobarg, Arginine methylation analysis of the splicing-associated SR protein SFRS9/SRP30C Cellular & Molecular Biology Letters. ,vol. 14, pp. 657- 669 ,(2009) , 10.2478/S11658-009-0024-2
R J van Alphen, E A C Wiemer, H Burger, F A L M Eskens, The spliceosome as target for anticancer treatment. British Journal of Cancer. ,vol. 100, pp. 228- 232 ,(2009) , 10.1038/SJ.BJC.6604801
Hirofumi Yoshino, Hideki Enokida, Takeshi Chiyomaru, Shuichi Tatarano, Hideo Hidaka, Takeshi Yamasaki, Takenari Gotannda, Tokushi Tachiwada, Nijiro Nohata, Takashi Yamane, Naohiko Seki, Masayuki Nakagawa, Tumor suppressive microRNA-1 mediated novel apoptosis pathways through direct inhibition of splicing factor serine/arginine-rich 9 (SRSF9/SRp30c) in bladder cancer. Biochemical and Biophysical Research Communications. ,vol. 417, pp. 588- 593 ,(2012) , 10.1016/J.BBRC.2011.12.011
Shuo Peng, Jianlin Geng, Rui Sun, Zhigang Tian, Haiming Wei, Polyinosinic-polycytidylic acid liposome induces human hepatoma cells apoptosis which correlates to the up-regulation of RIG-I like receptors Cancer Science. ,vol. 100, pp. 529- 536 ,(2009) , 10.1111/J.1349-7006.2008.01062.X
Carlo La Vecchia, Stefania Boccia, Oral contraceptives, human papillomavirus and cervical cancer. European Journal of Cancer Prevention. ,vol. 23, pp. 110- 112 ,(2014) , 10.1097/CEJ.0000000000000000
Tao Tang, Hoi Kin Wong, Wenyi Gu, Mei-yung Yu, Ka-Fai To, Chi Chiu Wang, Yick Fu Wong, Tak Hong Cheung, Tony Kwok Hung Chung, Kwong Wai Choy, MicroRNA-182 plays an onco-miRNA role in cervical cancer Gynecologic Oncology. ,vol. 129, pp. 199- 208 ,(2013) , 10.1016/J.YGYNO.2012.12.043