Reductive stress in microbes: implications for understanding Mycobacterium tuberculosis disease and persistence.

摘要: Abstract Mycobacterium tuberculosis ( Mtb ) is a remarkably successful pathogen that capable of persisting in host tissues for decades without causing disease. Years after initial infection, the bacilli may resume growth, outcome which active (TB). In order to establish resist defences and re-emerge, must coordinate its metabolism with vivo environmental conditions nutrient availability within primary site lung. Maintaining metabolic homeostasis an intracellular such as requires carefully orchestrated series oxidation–reduction reactions, which, if unbalanced, generate oxidative or reductive stress. The importance stress microbial pathogenesis has been appreciated well studied over past several decades. However, role counterpart, stress, largely ignored. Reductive defined aberrant increase reducing equivalents, magnitude identity determined by carbon source utilisation influenced presence host-generated gases (e.g. NO, CO, O 2 CO ). This increased power be dissipated bacterial survival. To recycle microbes have evolved unique electron ‘sinks’ are distinct their particular niche. this review, we describe specific mechanisms some dispel intention review introduce concept research particular, hope stimulating new avenues investigation.