Protein Kinase C Signaling and Expression of the Diabetic Cardiac Phenotype

摘要: The focus of this review will be recent advances in the molecular biology protein kinase C (PKC) signaling cardiac myocytes and application these novel techniques to study pathobiology diabetic myopathy. PKC family serine/threonine kinases have been implicated a diverse array biologic responses health disease. Compelling evidence has linked hyperglycemia mediated cell injury. Although myocyte not traditionally considered major target for insulin, high ambient concentration glucose promotes activation isozymes, that physiologically relevant intracellular substrates. availability genetically engineered mice, with targeted distinct isozyme (PKCe) muscle cells development selective peptide modulators, provides an approach examine events heart, explore vivo vitro consequences cascade. rapid growth knowledge area is critical therapeutic strategies potential arrest or reverse progression cardiomyopathy.