A unique mRNA species for a regulatory subunit of cAMP-dependent protein kinase is specifically induced in haploid germ cells
作者： Ole Øyen , John D. Scott , Gary G. Cadd , G.Stanley McKnight , Edwin G. Krebs
DOI: 10.1016/0014-5793(88)81163-3
关键词:
摘要: Cyclic AMP (cAMP) and its action by way of cAMP-dependent protein kinase is important for sperm motility. Previous studies on germ cells have demonstrated a selective decrease in the amount type I during spermatid development, that II was major form present elongating spermatids mature sperm. This would indicate activation gene haploid cells, encoding regulatory subunit kinase. However, expression such has so far not been shown. In study we demonstrate high-levelled unique mRNA species specific at late stages spermatogenesis, i.e. elongation.
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sci-hub.se 参考文章(22)
T Jahnsen, L Hedin, V J Kidd, W G Beattie, S M Lohmann, U Walter, J Durica, T Z Schulz, E Schiltz, M Browner, Molecular cloning, cDNA structure, and regulation of the regulatory subunit of type II cAMP-dependent protein kinase from rat ovarian granulosa cells. Journal of Biological Chemistry. ,vol. 261, pp. 12352- 12361 ,(1986) , 10.1016/S0021-9258(18)67247-3
M D Uhler, J C Chrivia, G S McKnight, Evidence for a second isoform of the catalytic subunit of cAMP-dependent protein kinase. Journal of Biological Chemistry. ,vol. 261, pp. 15360- 15363 ,(1986) , 10.1016/S0021-9258(18)66717-1
M O Showers, R A Maurer, A cloned bovine cDNA encodes an alternate form of the catalytic subunit of cAMP-dependent protein kinase. Journal of Biological Chemistry. ,vol. 261, pp. 16288- 16291 ,(1986) , 10.1016/S0021-9258(18)66561-5
M. D. Uhler, D. F. Carmichael, D. C. Lee, J. C. Chrivia, E. G. Krebs, G. S. McKnight, Isolation of cDNA clones coding for the catalytic subunit of mouse cAMP-dependent protein kinase Proceedings of the National Academy of Sciences of the United States of America. ,vol. 83, pp. 1300- 1304 ,(1986) , 10.1073/PNAS.83.5.1300
Joseph S. Tash, Sham S. Kakar, Anthony R. Means, Flagellar motility requires the cAMP-dependent phosphorylation of a heat-stable NP-40-soluble 56 kd protein, axokinin Cell. ,vol. 38, pp. 551- 559 ,(1984) , 10.1016/0092-8674(84)90509-9
Brian A. Hemmings, Manuela Schwarz, S. Rao Adavani, David A. Jans, Expression cloning of a cDNA encoding the type II regulatory subunit of the cAMP-dependent protein kinase. FEBS Letters. ,vol. 209, pp. 219- 222 ,(1986) , 10.1016/0014-5793(86)81114-0
S. M. Lohmann, P. DeCamilli, I. Einig, U. Walter, High-affinity binding of the regulatory subunit (RII) of cAMP-dependent protein kinase to microtubule-associated and other cellular proteins. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 81, pp. 6723- 6727 ,(1984) , 10.1073/PNAS.81.21.6723
R. Distel, K. Kleene, N. Hecht, Haploid expression of a mouse testis alpha-tubulin gene. Science. ,vol. 224, pp. 68- 70 ,(1984) , 10.1126/SCIENCE.6701535
O. Øyen, A. Frøysa, M. Sandberg, W. Eskild, D. Joseph, V. Hansson, T. Jahnsen, Cellular localization and age-dependent changes in mRNA for cyclic adenosine 3',5'-monophosphate-dependent protein kinases in rat testis. Biology of Reproduction. ,vol. 37, pp. 947- 956 ,(1987) , 10.1095/BIOLREPROD37.4.947
RB Vallee, MJ DiBartolomeis, WE Theurkauf, A protein kinase bound to the projection portion of MAP 2 (microtubule-associated protein 2) Journal of Cell Biology. ,vol. 90, pp. 568- 576 ,(1981) , 10.1083/JCB.90.3.568