Loss of p53 Induces Changes in the Behavior of Subventricular Zone Cells: Implication for the Genesis of Glial Tumors

摘要: The role of multipotential progenitors and neural stem cells in the adult subventricular zone (SVZ) as cell-of-origin glioblastoma has been suggested by studies on human tumors transgenic mice. However, it is still unknown whether glial are generated all heterogeneous SVZ cell types or only specific subpopulations cells. It proposed that transformation could result from lack apoptosis increased self-renewal, but definition properties leading to neoplastic elusive. This study addresses these questions mice carrying deletion p53, a tumor-suppressor gene expressed SVZ. We show here that, although loss p53 itself not sufficient for tumor formation, provides proliferative advantage slow- fast-proliferating populations associated with their rapid differentiation. results areas density distributed along walls lateral ventricles often p53-independent apoptosis. Transformation occurs when mutagenic stimulus characterized dramatic changes quiescent cells, including enhanced recruitment compartment, impaired Together, findings provide cellular mechanism how slow-proliferating can give rise brain.