Standardized measures of lobular involution and subsequent breast cancer risk among women with benign breast disease: a nested case-control study.

摘要: Lesser degrees of terminal duct-lobular unit (TDLU) involution predict higher breast cancer risk; however, standardized measures to quantitate levels TDLU have only recently been developed. We assessed whether three involution, with high intra/inter pathologist reproducibility in normal tissue, subsequent risk among women the Mayo benign disease (BBD) cohort. performed a masked evaluation biopsies from 99 BBD who subsequently developed (cases) after median 16.9 years and 145 age-matched controls. metrics inversely related involution: count/mm2, span (microns, which approximates acini content), category counts/TDLU (0–10; 11–20; 21–30; 31–50; >50). Associations for quartiles (or categories counts) each these were multivariable conditional logistic regression estimate odds ratios (ORs) 95 % confidence intervals (CI). In models, highest quartile compared lowest counts significantly associated diagnoses; quartile4 versus quartile1, OR = 2.44, 95 %CI 0.96–6.19, p-trend = 0.02; spans, OR = 2.83, 95 %CI = 1.13–7.06, p-trend = 0.03. Significant associations categorical also observed: 25 at risk, OR = 3.40, 1.03–11.17, p-trend = 0.032. Women spans count above further increased OR = 3.75 (95 %CI 1.40–10.00, p-trend = 0.008), below both metrics. Similar results observed combinatorial counts/TDLU, count. Standardized quantitative approximated by or visually are independently risk. Visual assessment numbers content, highly reproducible between pathologists, could help identify million diagnosed annually US.