Insulin-like growth factor-1, insulin-like growth factor binding protein-3 and lobule type in the Nurses' Health Study II
作者： Megan S Rice , Rulla M Tamimi , James L Connolly , Laura C Collins , Dejun Shen
DOI: 10.1186/BCR3141
关键词:
摘要: Introduction Previous research in the Nurses' Health Study (NHS) and NHSII observed that, among women diagnosed with benign breast disease (BBD), those predominant type 1/no 3 lobules (a marker of complete involution) versus other lobule types were at lower risk subsequent cancer. Studies animal models suggest that insulin-like growth factor-1 (IGF-1) may inhibit involution breast; however, this has not been studied humans.
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