Heart failure as an autonomic nervous system dysfunction.

摘要: In heart failure, it has been recognized that the sympathetic nervous system (SNS) is activated and imbalance of activity SNS vagal interaction occurs. The abnormal activation leads to further worsening failure. Many previous clinical basic studies have demonstrated caused by enhancement excitatory inputs including changes in: (1) peripheral baroreceptor chemoreceptor reflexes; (2) chemical mediators control outflow; (3) central sites integrate outflow. particular, abnormalities in regulation due renin angiotensin system-oxidative stress axis recently focus. treatment inhibition SNS, such as with beta-blockers and/or exercise training, important. Furthermore, many experimental stimulation beneficial effects on several also a possible novel therapy for conclusion, we must recognize failure complex syndrome an autonomic dysfunction, reduction should be treated.