Cerebrospinal fluid apolipoprotein E, calcium and cerebral vasospasm after subarachnoid hemorrhage.

摘要: Intracellular calcium (Ca++) regulation of cerebral vessels is impaired after subarachnoid hemorrhage (SAH), making secondary pathways, such as that involving apolipoprotein E, potentially more influential. To evaluate cerebrospinal fluid (CSF) E and Ca++ levels biomarkers vasospasm, we examined changes in over time (APOE) epsilon4 allele presence SAH individuals with without vasospasm. We hypothesized low levels, increased and/or at least one copy the APOE would have Daily samples from 50 participants, aged 18-75, were used to quantify levels. Vasospasm was verified using angiogram elevated transcranial Dopplers combination clinical neurologic deterioration. Overall higher (p = .02) or angiographic vasospasm .01), but there no differences between symptomatic There significant time. Individuals had lower trends suggesting a different pattern change .07). CSF < .01). Change .006) correlated regardless genotype status. These findings suggest may be interacting SAH, this interaction does not appear influence