Inhibition of mRNA synthesis in the hippocampus impairs consolidation and reconsolidation of spatial memory.
作者： Weber C Da Silva , Juliana S Bonini , Lia RM Bevilaqua , Jorge H Medina , Iván Izquierdo
DOI: 10.1002/HIPO.20362
关键词:
摘要: Using two different mRNA synthesis inhibitors, we show that blockade of hippocampal gene expression during restricted posttraining or postretrieval time windows hinders retention long-term spatial memory for the Morris water maze task, without affecting short-term memory, nonspatial learning, functionality hippocampus. Our results indicate consolidation induces activation transcriptional machinery and suggest existence a expression-dependent reconsolidation process operates in dorsal hippocampus at moment retrieval to stabilize reactivated mnemonic trace.
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