Gastric and intestinal phenotypic cell marker expressions in gastric differentiated-type carcinomas: association with E-cadherin expression and chromosomal changes

摘要: Gastric and intestinal phenotypic cell markers are widely expressed in gastric carcinomas, irrespective of their histological type. In the present study, relations between marker expression tumour, findings, adhesion molecules, chromosomal changes differentiated-type carcinomas were examined. The tumour was determined by combination human mucin (HGM), MUC6, MUC2 CD10, evaluated comparison with such as E-cadherin β-catenin, comparative genomic hybridization (CGH) 34 carcinomas. Tumours classified into gastric- (G-), mixed- (GI-), intestinal- (I-), or unclassified- (UC-) phenotype according to immunopositivity staining for HGM, MUC2, CD10. G-phenotype tumours significantly associated a higher incidence mixed undifferentiated-type component, compared GI- I-phenotype (88.9 vs 33.3%, P=0.0498 88.9 42.9%, P=0.0397; respectively). HGM-positive abnormal E-cadherin, HGM-negative (66.7 21.1%, P=0.0135). GI-phenotype (77.8 21.4%, P=0.0131). frequencies gains 19q13.2 19q13.3, (57.9 20.0%, P=0.0382 63.2 13.3%, P=0.0051; MUC6-positive 20q13.2, MUC6-negative (71.4 30.0%, P=0.0349). MUC2-positive gain 19p13.3, MUC2-negative (41.2 5.9%, P=0.0391). 5p15.2 13q33-34, 0%, P=0.0481, each) also 7p21, P=0.0481). Our results show that have different characteristics terms pattern changes.