Prognostic value of hypoxia inducible factor 1α in esophageal squamous cell carcinoma.
作者： P. C. Munipalle , Y. K. S. Viswanath , P. A. Davis , D. Scoones
DOI: 10.1111/J.1442-2050.2010.01122.X
关键词:
摘要: Hypoxia inducible factor 1α (HIF 1α) plays a major role in the pleitropic response observed secondary to hypoxic conditions tumors. Its expression tumor cells has been correlated aggressiveness and prognosis squamous cell carcinoma (SCC) of esophagus Far Eastern population, but limited information is available on prognostic HIF SCC European population. This may help choosing appropriate therapeutic strategies possibly developing monoclonal antibody with potential targeting 1α. Tumor samples from 36 patients diagnosed were collected. Prepared tissue sections stained validated specific antibodies for was disease pattern survival. Out patients, 17 showed low 19 high There no difference disease-free overall survival between these two groups (P > 0.05, log rank test). Regression analysis that not an independent 0.05). did show value our study agreement previous studies. Novel manipulation cancer are be explored further have play improving treatment outcome.
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sci-hub.se 参考文章(19)
Yong-Hong Shi, Wei-Gang Fang, Hypoxia-inducible factor-1 in tumour angiogenesis World Journal of Gastroenterology. ,vol. 10, pp. 1082- 1087 ,(2004) , 10.3748/WJG.V10.I8.1082
TNM classification of malignant tumours Published in <b>2010</b> in Chichester, West Sussex, UK ;Hoboken, NJ by Wiley-Blackwell. ,(1987) , 10.1007/978-3-642-82982-6
Tomokazu Matsuyama, Kuniaki Nakanishi, Takuya Hayashi, Yutaka Yoshizumi, Satoshi Aiko, Yoshiaki Sugiura, Takao Tanimoto, Maki Uenoyama, Yuichi Ozeki, Tadaaki Maehara, Expression of hypoxia-inducible factor-1alpha in esophageal squamous cell carcinoma. Cancer Science. ,vol. 96, pp. 176- 182 ,(2005) , 10.1111/J.1349-7006.2005.00025.X
Miwako Katsuta, Masao Miyashita, Hiroshi Makino, Tsutomu Nomura, Seiichi Shinji, Kiyohiko Yamashita, Takashi Tajiri, Mitsuhiro Kudo, Toshiyuki Ishiwata, Zenya Naito, Correlation of hypoxia inducible factor-1α with lymphatic metastasis via vascular endothelial growth factor-C in human esophageal cancer Experimental and Molecular Pathology. ,vol. 78, pp. 123- 130 ,(2005) , 10.1016/J.YEXMP.2004.11.002
Eun-Jin Yeo, Yang-Sook Chun, Jong-Wan Park, New anticancer strategies targeting HIF-1. Biochemical Pharmacology. ,vol. 68, pp. 1061- 1069 ,(2004) , 10.1016/J.BCP.2004.02.040
T Kurokawa, M Miyamoto, K Kato, Y Cho, Y Kawarada, Y Hida, T Shinohara, T Itoh, S Okushiba, S Kondo, H Katoh, Overexpression of hypoxia-inducible-factor 1alpha(HIF-1alpha) in oesophageal squamous cell carcinoma correlates with lymph node metastasis and pathologic stage. British Journal of Cancer. ,vol. 89, pp. 1042- 1047 ,(2003) , 10.1038/SJ.BJC.6601186
Yongshun Chen, You Lu, Changli Lu, Lei Zhang, Beclin-1 Expression is a Predictor of Clinical Outcome in Patients with Esophageal Squamous Cell Carcinoma and Correlated to Hypoxia-Inducible Factor (HIF)-1α Expression Pathology & Oncology Research. ,vol. 15, pp. 487- 493 ,(2009) , 10.1007/S12253-008-9143-8
Cristina Bosetti, Fabio Levi, Jacques Ferlay, Werner Garavello, Franca Lucchini, Paola Bertuccio, Eva Negri, Carlo La Vecchia, Trends in oesophageal cancer incidence and mortality in Europe. International Journal of Cancer. ,vol. 122, pp. 1118- 1129 ,(2007) , 10.1002/IJC.23232
Gregg L. SEMENZA, Involvement of hypoxia-inducible factor 1 in human cancer. Internal Medicine. ,vol. 41, pp. 79- 83 ,(2002) , 10.2169/INTERNALMEDICINE.41.79
Shigeru Kimura, Yasuhiko Kitadai, Shinji Tanaka, Toshio Kuwai, Jun Hihara, Kazuhiro Yoshida, Tetsuya Toge, Kazuaki Chayama, Expression of hypoxia-inducible factor (HIF)-1α is associated with vascular endothelial growth factor expression and tumour angiogenesis in human oesophageal squamous cell carcinoma European Journal of Cancer. ,vol. 40, pp. 1904- 1912 ,(2004) , 10.1016/J.EJCA.2004.04.035