Correlation of hypoxia inducible factor-1α with lymphatic metastasis via vascular endothelial growth factor-C in human esophageal cancer

摘要: Hypoxia inducible factor (HIF)-1alpha is a transcription that regulates the of genes associated with cell proliferation and vascular development. In various cancer tissues, HIF-1alpha clinicopathological factors, such as tumor size, histological grade, lymph node status. Although plays critical role in growth by inducing endothelial (VEGF), it unclarified whether affects lymphatic metastasis. The purpose this study to clarify correlation protein expression metastasis esophageal squamous carcinoma (ESCC). expressions VEGF-C, which one main lymphangiogenic were examined five ESCC lines 48 surgical specimens ESCC. VEGF-C mRNAs expressed all determined RT-PCR analysis. Immunohistochemically, 34 patients (70.8%) positive for 29 (60.4%) VEGF-C. Clinicopathologically, correlated invasion (P = 0.003 P 0.01, respectively). Furthermore, tended correlate 0.09). These findings suggest through induction